Biologic medications represent one of the most significant advances in medicine over the past two decades. They have transformed outcomes for patients with conditions like atopic dermatitis, psoriasis, rheumatoid arthritis, and Crohn’s disease.
What Is a Biologic?
Unlike traditional medications that are chemically synthesized, biologics are derived from living cells, typically bacteria, yeast, or mammalian cells. They are large, complex molecules (usually proteins) designed to target very specific parts of the immune system.
How Do Biologics Work for Skin Conditions?
In conditions like atopic dermatitis and psoriasis, the immune system becomes dysregulated, producing inflammatory signals that damage the skin. Biologic medications work by targeting and blocking specific proteins involved in these inflammatory pathways.
For example: – Dupilumab (Dupixent) blocks IL-4 and IL-13 receptors in atopic dermatitis – Nemolizumab (NEMLUVIO) blocks IL-31 receptor A in atopic dermatitis – Secukinumab (Cosentyx) blocks IL-17A in psoriasis – Risankizumab (Skyrizi) blocks IL-23 in psoriasis
How Are Biologics Given?
Most biologics are given as injections (subcutaneous or intravenous). They cannot be taken as a pill because they would be broken down by digestion before reaching the target.
Are Biologics Safe?
Biologics have a generally favorable safety profile. Because they suppress parts of the immune system, the main concerns include increased susceptibility to certain infections. Your research team will monitor you carefully.
Biologics in Clinical Trials
Many biologic candidates are still in clinical trials. Participating in a biologic trial may give you access to a treatment not yet on the market. Browse our studies to see what is available at NuLine.